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The name "DeVille" ("of the city" or "town" in French) derives its name from its body styling, which featured an open chauffeur's compartment and enclosed passenger compartment. This configuration elevated the vehicle from mere transportation to a bona fide status symbol. The first Cadillac to bear the name Deville was the 1949 Coupe De Ville, with a 4-door hardtop version appearing in 1956. Both cars were based on the Series 62. Beginning in 1965, DeVille denoted Cadillac's mainstream model, falling between the Calais and the Fleetwood.

For 1968, the DeVille gained slight exterior changes to comply with new federal safety and emissions legislation, and as with the rest of the Cadillac lineup, a new 472 (7.7 L) V8 engine rated at 375 hp.

In November 1971, a showroom-stock 1971 Coupe DeVille placed third in the annual coast-to-coast Cannonball Run, posting the highest average speed of the event, 84.6 mph (excluding stops) and averaging 8.9 miles per gallon.

DeVilles have always been a notable car throughout history and have been used countless times by politicians, spiritual leaders, and are notable in many movies.

The Cadillac DTS (DeVille Touring Sedan) is a full-size luxury sedan from Cadillac and is the largest sedan offered by General Motors. The DTS replaced the Cadillac DeVille as that carmaker's largest luxury car in the 2006 model year, following the naming and styling direction set by the earlier CTS and STS.

The design of the DTS was introduced in a unique way. A specially designed and outfitted presidential DTS limousine was utilized during the second inauguration of George W. Bush in the January 20, 2005 parade. While details of the vehicle, codenamed Stagecoach, are highly classified, it is presumed to be heavily armored and feature advanced communication equipment. The production DTS was shown at the 2005 Chicago Auto Show on February 9.